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Revista Portuguesa de Estomatologia,
Medicina Dentária e Cirurgia Maxilofacial
Portuguese Journal of Stomatology, Dental Medicine and Maxillofacial Surgery

rev port estomatol med dent cir maxilofac. 2026;67(1):40-46

Clinical Case Report

Six-year follow-up of regenerative endodontics
in a maxillary central incisor with apical

periodontitis: Case report

1
Ary Alves Mesquita-Júnior * , Ingrid Luiza Mendonça Cunha ,
1,
2
Norbi Rodrigues Correia , Aida Renée Assayag Hanan ,
1
1
Emílio Carlos Sponchiado Júnior
1 Federal University of Amazonas, School of Dentistry, Manaus, Brazil.
2 Ceproeducar, Manaus, Brazil

a r t i c l e i n f o a b s t r a c t

Article history: Regenerative endodontics is a biological alternative to apexification for managing immature
Received 21 June 2025 teeth with pulp necrosis or irreversible pulpitis. This case report provides clinical relevance
Accepted 11 March 2026 by demonstrating the 6-year success of a regenerative endodontic procedure using accessi-
Available online 23 April 2026 ble materials and a reproducible protocol. A 12-year-old male presented with a traumatized
maxillary central incisor showing crown discoloration, incomplete root formation, and a
Keywords: periapical lesion. Treatment was completed in two sessions. The first involved coronal ac-
Apexification cess, irrigation with 2.5% sodium hypochlorite, and placement of a bi-antibiotic paste. In the
Case reports second session, the paste was removed, and sodium hypochlorite was neutralized with
Dental pulp necrosis saline solution. After drying, bleeding was induced, and a calcium silicate-based cement
Periapical periodontitis plug was placed, followed by coronal restoration. At the 6-year follow-up, the patient re-
Regenerative endodontics mained symptom-free, and imaging showed resolution of apical periodontitis, root elonga-
tion, and dentinal wall thickening. This case highlights the long-term success of regenerative
procedures promoting root development and periapical healing. (Rev Port Estomatol Med
Dent Cir Maxilofac. 2026;67(1):40-46)
© 2026 Sociedade Portuguesa de Estomatologia e Medicina Dentária.
Published by SPEMD. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

* Corresponding author.
E-mail address: aamesquitajunior@gmail.com (Ary Alves Mesquita-Júnior)
http://doi.org/10.24873/j.rpemd.2026.04.1566
1646-2890/© 2026 Sociedade Portuguesa de Estomatologia e Medicina Dentária. Published by SPEMD.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).