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rev port estomatol med dent cir maxilofac . 2020;61(2):57-63 61

Table 1. Studies that assessed the application of 0.8% HA for chronic periodontitis treatment.
Author Results

Shah et al., 2017 9 PI: PPD:
Test Group: 2.41% to 1.81%. Test Group: 5.37 mm to 2.37 mm.
Control Group: 2.33% to 1.82%. Control Group: 5.37 mm to 3.33 mm.
GI: RAL:
Test Group: 2.36% to 1.74%. Test Group: 9.17 mm to 6.70 mm.
Control Group: 2.28% to 1.76%. Control Group: 9.10 mm to 7.50 mm.
Salavadhi et al., 2016 8 PI: BOP:
Test Group: 2.28% to 0.60%. Test Group: 95.64% to 28.45%.
Control Group: 2.45% to 0.94%. Control Group: 98.47% to 38.32%.
PPD: CAL:
Test Group: 7.33 mm to 4.5 mm. Test group: 7.58 mm to 4.67 mm.
Control Group: 6.92 mm to 5.25 mm. Control Group: 7.67 mm to 6 mm.
Shammari, et al., 2016 12 PPD: BOP:
Test Group: 4.9 mm to 305 mm. Test Group: 24.48% to 16.45%.
Control Group: 4.85 mm to 3.5 mm. Control Group: 24.52% to 28.55%.
CAL: GI:
Test Group: 3.78 mm to 2.69 mm. Test Group: 25.29% to 15.77%.
Control Group: 3.34 mm to 2.69 mm. Control Group: 23.71% to 29.23%.
PI:
Test Group: 26.38% to 23.14%.
Control Group: 22.63% to 21.86%.
Polepalle et al., 2015 10 BOP: PPD:
Test Group: 1.00% to 0.22%. Test Group: 4.99 mm to 5.21 mm.
Control Group: 1.00% to 0.80%. Control Group: 2.45 mm to 4.49 mm.
PI: CAL:
Test Group: 2.05% to 0.40%. Test Group: 5.4 mm to 2.73 mm.
Control Group: 2.15% to 1.90%. Control Group: 5.41 mm to 4.71 mm.
PI – plaque index; GI – gingival index; BOP – bleeding on probing; PPD – probing depth; CAL – clinical attachment level; RAL – residual clinical
attachment

Table 2. Studies that assessed the application of 0.2% HA for chronic periodontitis treatment.
Author Results
Rajan et al., 2014 13 PPD: BOP:
Test Group: 6.33 mm to 2.49 mm. Test Group: 1.00% to 0.06%.
Control Group: 6.09 mm to 4.36 mm. Control Group 1.00% to 0.48%.
CAL:
Test Group: 10.18 mm to 6.91 mm.
Control Group 9.12 mm to 7.48 mm.
Xu et al., 2004 11 PPD: BOP:
Test Group: 5.3 mm to 4.3 mm. Test Group: 78% to 19%.
Control Group: 5.2 mm to 4.2 mm. Control Group: 72% to 23%.
Microbiological Parameters: CAL:
Test Group: Aa- 35% to 35%; Pg- 65% to 50%; Tf -85% to 70%. Test Group: 5.5 mm to 4.5 mm.
Control Group: Aa- 35% to 30%; Pg- 65% to 60%; Tf- 90% to 70%. Control Group: 5.4 mm to 4.5 mm.

Gontiya et al., 2012 2 PPD: BOP:
Test Group: 6.57 mm to 4.82 mm. Test Group: 1.00% to 0.02%.
Control Group: 6.42 mm to 4.94 mm. Control Group: 1.00% to 0.21%.
GI: RAL:
Test Group: 2.02% to 0.89%. Test Group: 8.91 mm to 7.60 mm.
Control Group: 2.04% to 1.19%. Control Group: 8.56 mm to 7.64 mm.
GI – gingival index; BOP – bleeding on probing; PPD – probing depth; CAL – clinical attachment level; RAL – residual clinical attachment; Aa – Ag-
gregatibacter Actinomycetemcomitans; Pg – Porphyromonas Gingivalis; Tf – Tannerella Forsythia

causing an immune or inflammatory response. It has visco- odontal inflammation and healing when used alone or as
elastic properties, which allow it to act as a barrier against an adjunct to periodontal mechanical therapy. Indeed, most
5
periodontal pathogens and make it easier to be used in the of the studies exposed in this literature review confirm that
form of a gel, with easy application. 5 the use of HA as an adjuvant to scaling seems to obtain
Additionally, it has a pro-angiogenic, anti-inflammatory, better results in the treatment of periodontitis than scaling
and bacteriostatic role, which positively influences peri- alone. 8-11,13