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Revista Portuguesa de Estomatologia,
Medicina Dentária e Cirurgia Maxilofacial

rev port estomatol med dent cir maxilofac. 2020;61(2):57-63

Original research

The role of hyaluron acid in non‑surgical treatment
of Chronic Periodontitis – Systematic review

b
a
a
a,
Vanessa Rocha Rodrigues *, Pedro Rocha , Pedro Otão , Henrique Luis ,
c
Susana Noronha , Paulo Mascarenhas c
a Médico(a) Dentista, Aluno/a da especialização de Periodontologia e Implantes da Faculdade de Medicina Dentária de Lisboa, Lisboa, Portugal.
b Higienista Oral, Coordenador do Departamento de Higiene Oral da Faculdade de Medicina Dentária da Universidade de Lisboa.
c Médico(a) Dentista, Especialista em Periodontologia pela OMD, Professor(a) Auxiliar do Departamento de Periodontologia na FMDUL.
Coordenador e Docente da Especialização em Periodontologia e Implantes na FMDUL.

a r t i c l e i n f o a b s t r a c t

Article history: Objectives: The purpose of this review is to perform a systematic evaluation of the clinical
Received 28 November 2019 effects of the local subgingival use of 0.8% or 0.2% hyaluronic acid (HA) as an adjunct to
Accepted 8 August 2020 scaling and root planning in patients with chronic periodontitis.
Available online 11 September 2020 Methods: An electronic search was performed on PubMed, Lilacs, and Cochrane, without any
time or language restrictions, on May 9, 2018, using the following keywords: “hyaluronic
Keywords: acid”; “periodontitis”; “treatment of periodontitis”; and “scaling.” The following parameters
Hyaluronic acid were evaluated: clinical attachment level (CAL) gain, probing depth (PD), bleeding on probing
Periodontitis (BOP), plaque index (PI), and gingival index (IG). This review was registered with the identi-
Scaling fication number CRD42019131541 in the PROSPERO International Prospective Register of
Treatment of periodontitis Systematic Reviews hosted by the National Institute for Health Research, University of York,
Centre for Reviews and Dissemination.
Results: When applied to periodontitis, the combined treatment HA + SRP provides more
satisfactory results than the conventional treatment of SRP alone in most of the outcome
variables presented.
Conclusion: It can be concluded that hyaluronic acid is a chemical adjuvant to consider in
periodontal therapy. (Rev Port Estomatol Med Dent Cir Maxilofac. 2020;61(2):57-63)
© 2020 Sociedade Portuguesa de Estomatologia e Medicina Dentária.
Published by SPEMD. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

* Corresponding author.
E-mail address: Vanessa_15_rodrigues@hotmail.com (Vanessa Rocha Rodrigues).
http://doi.org/10.24873/j.rpemd.2020.09.703
1646-2890/© 2020 Sociedade Portuguesa de Estomatologia e Medicina Dentária. Published by SPEMD.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).