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118                    rev port estomatol med dent cir maxilofac. 2018;59(2):115-118


             In conclusion, according to our literature review, the head   11. Anadolu R, Akay BN, Bodamyali P, et al. Giant
           and neck giant KA is usually a rapid growth benign tumor with   keratoacanthoma -type low -grade squamous cell carcinoma
           a low propensity for recurrence or metastasis that presents a   of the upper lip: response to intralesional interferon
                                                                 alpha -2B. J Dermatolog Treat. 2011;22:239-40.
           predilection for male patients, affects mostly the nose and is   12. Lucente FE. Giant keratoacanthoma of the nose. Otolaryngol
           commonly treated by surgery alone. The case report here pre-  Head Neck Surg. 1985;93:112-6.
           sented revealed that tumor excision is an effective treatment   13. Phiske MM, Avhad G, Jerajani, HR. Keratoacanthoma
           and aesthetic principles need to be taken into account to have   centrifugum marginatum at an unusual site. Indian journal
           an optimal treatment and patient satisfaction.        of dermatology. 2013;58:74.
                                                              14. Browne F, O’Connell M, Merchant W, et al. Spontaneous
                                                                 resolution of a giant keratoacanthoma penetrating through
           Ethical disclosures                                   the nose. Clin Exp Dermatol. 2011;36:369-71.
                                                              15. Edelman BA, Jacobs JB, Rotterdam H, et al. Giant
                                                                 keratoacanthoma: an atypical presentation. Otolaryngol
           Protection of human and animal subjects. The authors de-  Head Neck Surg. 1990;103:472-5.
           clare that no experiments were performed on humans or an-  16. Saito M, Sasaki Y, Yamazaki N, et al. Self -involution of giant
           imals for this study.                                 keratoacanthoma on the tip of the nose. Plast Reconstr Surg.
                                                                 2003;111:1561-2.
           Confidentiality of data. The authors declare that they have   17. Grob JJ, Suzini F, Richard MA, et al. Large keratoacanthomas
           followed the protocols of their work center on the publication   treated with intralesional interferon alfa -2a. J Am Acad
           of patient data.                                      Dermatol. 1993;29:237-41.
                                                              18. Spieth K, Gille J, Kaufmann R. Intralesional methotrexate as
           Right to privacy and informed consent. The authors have ob-  effective treatment in solitary giant keratoacanthoma of the
           tained the written informed consent of the patients or sub-  lower lip. Dermatology. 2000;200:317-9.
           jects mentioned in the article. The corresponding author is in   19. Rapaport J. Giant keratoacanthoma of the nose. Arch
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                                                                 aggressive giant keratoacanthoma of the face. J Dermatol
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           Conflicts of interest                              21. Salam MA, Bickerton RC. Giant keratoacanthoma of the nasal
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                                                                 Hanemann JA. Giant keratoacanthoma of the lower lip: case
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