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Rapid desensitization to acetylsalicylic acid in patients with

ischemic heart disease: 10-year experience of a portuguese

allergy department

Dessensibilização rápida ao ácido acetilsalicílico em doentes
com cardiopatia isquémica: experiência de 10 anos de um serviço

de imunoalergologia português

1,2
1
R Brás , J Caiado , E Pedro 1
1 Department of Immunoallergology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
2 University Clinic of Immunoallergology, Faculty of Medicine, Universidade de Lisboa, Lisbon, Portugal.
Eur Ann Allergy Clin Immunol. 2021 Jul 26. Epub ahead of print. PMID: 34313087
DOI: 10.23822/EurAnnACI.1764-1489.230

ABSTRACT

Introduction: Managing Acetylsalicylic Acid (ASA) hypersensitivity (HS) in patients with ischemic heart disease (IHD)
is a challenge. Data on Rapid Desensitization (RD) to ASA is scarce. We aimed to report the outcomes of our 10-year
experience with RD to ASA. Methods: Retrospective, observational, single-center study of patients with ASA HS and
suspected IHD who underwent RD to ASA between March 2009 and February 2019. Results: Fifty patients were
included. ASA HS presentation ranged from urticaria (56%) to anaphylaxis (32%). Regarding cardiologic diagnoses,
40 patients (80%) had acute coronary syndrome and 10 (20%) stable angina. The majority of patients (N=36,72%)
underwent percutaneous coronary intervention. RD to ASA was successful in all patients. Two patients presented a
mild HS reaction during the RD, which was promptly treated, and subsequent daily doses of ASA 100mg were
tolerated. Conclusions: In our cohort, RD to ASA in patients with ASA HS and IHD was very effective and safe.

Keywords: Acetylsalicylic acid, hypersensitivity, desensitization, ischemic heart disease, percutaneous coronary
intervention.

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