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Elementos-chave nas reações de hipersensibilidade a

quimioterapia: A experiência com protocolos de dessensibilização

rápida em oncologia ginecológica num hospital terciário

Key elements in hypersensitivity reactions to chemotherapy:
Experience with rapid drug desensitization in gynaecological cancer

in a tertiary hospital

2,3
1
2
1
Iolanda Alen Coutinho , Filipa Costa Sousa , Francisca Cunha , Cristina Frutuoso , Carmelita Ribeiro , Carlos
1
Loureiro , Fernanda Águas , Ana Todo Bom 1,4
1
2
1 Allergy and Clinical Immunology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
2 Ginecology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
3 Coimbra Clinical Academic Center, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
4 Institute of Pathophysiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Eur Ann Allergy Clin Immunol. 2021 May 4. Epub ahead of print. PMID: 33944544
DOI: 10.23822/eurannaci.1764-1489.207
ABSTRACT
Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered equally effective.
The aim of our study is to describe the experience with RDD to cytostatics in patients being treated for gynaecological
cancer in a tertiary hospital, over a period of 5 years. In this paper, we review 22 cases and 107 episodes of RDD;
86.3% of patients had advanced disease and the mortality rate at the time of data collection was 50.0%. RDD was
performed on 81.8% patients for platinum, 13.6% for taxanes, and 4.5% for anthracyclines. RDD has successfully
allowed the reintroduction of antineoplastic drugs in all patients with a previous history of immediate hypersensitivity
reaction, demonstrating the safety and efficacy of this procedure. There was serious complication (anaphylaxis) in
only one case.

Keywords: Adults, chemotherapy hypersensitivity reactions, gynaecological cancer, rapid desensitization, risk factors.

14 COLET ÂNEA DOS PRÉMIOS SP AIC–DIA TER