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Revista Portuguesa de Estomatologia,
Medicina Dentária e Cirurgia Maxilofacial
Portuguese Journal of Stomatology, Dental Medicine and Maxillofacial Surgery

rev port estomatol med dent cir maxilofac. 2026;67(1):34-39

Clinical Case Report

Rapidly growing peripheral giant cell granuloma:
A case report

2,
1
Edward Henry Miranda Gutiérrez , Hector Martin Vargas Cornejo * ,
2
2
Cesar Augusto Jiménez-Prado , Manuel Fernando Guillén-Galarza
1 Faculty of Human Medicine, Antenor Orrego Private University, Trujillo, Peru.
2 Faculty of Stomatology, National University of Trujillo, Trujillo, Peru.

a r t i c l e i n f o a b s t r a c t

Article history: Peripheral giant cell granuloma is a benign reactive gingival lesion associated with chron-
Received 24 February 2026 ic irritation. It typically presents as a reddish-violet mass that tends to bleed or ulcerate
Accepted 19 April 2026 and may be associated with underlying bone resorption. A 62-year-old woman presented
Available online 30 April 2026 with a three-month history of a painful, bleeding, pedunculated lesion extending from
the right mandibular canine to the second premolar. Radiographic findings suggestive of
Keywords: superficial cortical alteration were observed. The lesion was treated by complete surgical
Case reports excision using an elliptical incision, including removal of the pedicle and curettage of the
Gingival diseases underlying periosteum and superficial bone. Histopathological evaluation confirmed the
Giant cell granuloma diagnosis of peripheral giant cell granuloma. Local irritative factors were eliminated to
Oral pathology reduce the risk of recurrence. At the one-month follow-up, healing was satisfactory. Due
to the short follow-up period, recurrence cannot be assessed. This case highlights the
importance of early recognition and complete surgical management to prevent bone in-
volvement and guide appropriate treatment. (Rev Port Estomatol Med Dent Cir Maxilofac.
2026;67(1):34-39)
© 2026 Sociedade Portuguesa de Estomatologia e Medicina Dentária.
Published by SPEMD. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

gingival lesions, it accounts for only a small proportion of all
Introduction
oral lesions. PGCG occurs more often in adult females be-
2,4
Peripheral giant cell granuloma (PGCG) is a benign reactive le- tween the third and sixth decades of life and affects the man-
sion that arises from the periosteum or periodontal ligament dible, especially the anterior region. Its occurrence in elderly
1,3
and develops on the gingiva or alveolar mucosa. Clinically, it patients is less common and may pose a diagnostic challenge
appears as an exophytic nodule with a sessile or pedunculated because of its resemblance to other lesions. 3,4
base, usually reddish or purplish in color and with a tendency PGCG usually presents as a slow-growing lesion confined
to bleed. 1–3 Although it is among the most common reactive to the gingival soft tissues. However, variations in clinical be-

* Corresponding author.
E-mail address: hmvargasco@unitru.edu.pe (Hector Martin Vargas Cornejo)
http://doi.org/10.24873/j.rpemd.2026.04.1568
1646-2890/© 2026 Sociedade Portuguesa de Estomatologia e Medicina Dentária. Published by SPEMD.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).