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Inês Mota, Ângela Gaspar, Mário Morais-Almeida

NSAIDs hypersensitivity diagnosis is based on a de- 7. Gomes E, Cardoso MF, Praça F, Gomes L, Mariño E, Demoly P.
tailed clinical history. Skin tests are not routinely recom- Self -reported drug allergy in a general adult Portuguese popula-
tion. Clin Exp Allergy 2004;34:1597 -601.
mended in most of patients. Oral challenge tests are
8. Aun MV, Blanca M, Garro LS, Ribeiro MR, Kalil J, Motta AA, et al.
crucial to confirm the diagnosis, as well as to investigate Nonsteroidal anti -inflammatory drugs are major causes of drug-
safe alternative drugs. Acetaminophen and COX -2 selec- -induced anaphylaxis. J Allergy Clin Immunol Pract 2014;2:414 -20.
tive inhibitors (coxibs) or preferential inhibitors (meloxi- 9. Ribeiro -Vaz I, Marques J, Demoly P, Polonia J, Gomes ER. Drug-
-induced anaphylaxis: a decade review of reporting to the Portu-
cam) are typically well -tolerated and reasonable alterna-
guese Pharmacovigilance Authority. Eur J Clin Pharmacol
tives. Exceptionally, whether the culprit drug is considered 2013;69:673 -81.
indispensable or if it is not available an equivalent alterna- 10. Sole D, Ivancevich JC, Borges MS, Coelho MA, Rosario NA, Ar-
tive, desensitization can be achieved. dusso LRF, et al. Anaphylaxis in Latin America: a report of the
online Latin American survey on anaphylaxis (OLASA). Clinics
2011;66:943 -7.
Funding: None. 11. Kowalski ML, Makowska JS, Blanca M, Bavbek S, Bochenek G,
Conflicts of interest: None. Bousquet J, et al. Hypersensitivity to nonsteroidal anti-
-inflammatory drugs (NSAIDs) – classification, diagnosis and
management: review of the EAACI/ENDA(#) and GA2LEN/
Corresponding author: HANNA*. Allergy 2011;66:818 -29.
Inês Mota, MD 12. de Almeida MA, Gaspar AP, Carvalho FS, Nogueira JM, Pinto JE.
Centro de Imunoalergologia, Hospital CUF Descobertas Adverse reactions to acetaminophen, ASA, and NSAIDs in chil-
Rua Mário Botas dren: what alternatives? Allergy Asthma Proc 1997;18:313 -8.
1998 -018 Lisboa 13. Couto M, Gaspar A, Morais -Almeida M. Selective anaphylaxis to
Email: i.andrade.mota@gmail.com paracetamol in a child. Eur Ann Allergy Clin Immunol 2012;44:163 -6.
14. Blanca -López N, Cornejo -García JA, Pérez -Alzate D, Pérez-
-Sánchez N, Plaza -Serón MC, Doña I, et al. Hypersensitivity Re-
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