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rev port estomatol med dent cir maxilofac . 2019;60(3):118-124 121

Table 1. Manifestations felt and observed during Table 2. Decayed, missing and filled teeth (DMFT) index
chemotherapy. and simplified oral hygiene index (OHI-s).
Felt changes Observed changes Minimum Maximum Mean Std.
n (%) n (%) Deviation
Xerostomia 33 (71.7) Decayed teeth (n=47) 0 11 1.57 2.20
Ulcers/sores 14 (30.4) 11 (22.4) Missing teeth (n=47) 0 23 5.62 6.47
Infection 1 (2.2) Filled teeth (n=47) 0 18 3.91 4.54
Tooth mobility 6 (12.2) DMFT (n=47) 0 26 11.11 6.48
Hypersensitivity 18 (39.1) DI-s (n=42) 0.16 2 1.06 0.52
Halitosis 9 (18.4) 12 (24.5) CI-s (n=42) 0 3 1.18 0.52
Loss of appetite 14 (30.4) OHI-s (n=42) 0.5 5 2.24 0.94
Candidiasis 5 (102) DI-s, simplified debris index; CI-s, simplified calculus index.
White/red lesions 1 (2.2) 4 (8.2)
Mucositis 0 (0.0) 9 (18.4) very good and 18.4% as bad. Eleven patients (22.4%) rated
their quality of life as worst during CT (p=0.001; sign rank
Herpes simplex infection 1 (2.2) 0 (0.0)
test).
Tooth decay 1 (2.2) 20(42.6) The utilization of dental services before starting CT was
reported by 53.1% of the patients compared to 10.2% during
Dysgeusia 22 (47.8)
CT. Concerning patients that had already finished previous
Gingival changes 11 (23.9) 38 (77.6) cycles of CT, 53.8% of them had visited the dentist after the
completion of the cycle.
Mouth soreness 7 (15.2)
Forty-seven (95.9%) patients had natural teeth, and the
Tooth pain 4 (8.2) mean number of teeth was 21.1 (± 8.13). Thirteen (26.5%) pa-
tients wore dental prostheses. The DMFT was 11.11 (± 6.48),
Difficulty in speech 6 (12.2)
with the missing component contributing the most (5.62 ±
Difficulty in feeding 5 (10.2) 6.47). The OHI-s mean, which results from the sum of the de-
TMJ region pain 6 (12.2) bris and calculus indexes, was 2.24 (± 0.94), representing a fair
oral hygiene score (Table 2).
The intraoral and periodontal exam revealed the presence
When asked if their quality of life was affected during CT, of tooth recessions (73.5%), tooth mobility (12.2%) and gingival
most patients reported not at all (24.5%) or a little (38.8%), inflammation (77.6%). Halitosis was observed in 12 (24.5%)
whereas 36.7% reported very much. Regarding their self-as- patients.
sessed oral health, 51% of the patients rated their oral health The number of oral manifestations was not associated
before CT as good or very good and 4.1% as bad, while 40.8% with the number of CT cycles (p=0.436) but was associated with
of the patients rated their oral health during CT as good or the duration of the CT treatment (p= 0.014) (Table 3).

Table 3. Association between the number of oral manifestations and cycles and duration of chemotherapy, based on the
Kruskal-Wallis test.
Number of oral manifestations
0 1 2 3 4 5 p value
n (%) n (%) n (%) n (%) n (%) n (%)
1 2 (28.6) 1 (14.2) 2 (28.6) 0 (0.0) 2 (28.6) 0 (0.0)
2 to 3 3 (27.3) 2 (18.2) 3 (27.3) 3(27.3) 0(0.0) 0 (0.0)
Number 0.436
of cycles
4 to 5 1(7.1) 2 (14.3) 6 (42.9) 3(21.4) 2(14.3) 0(0.0)
6 or more 1(5.9) 5(29.4) 2(11.8) 6(35.2) 2 (11.8) 1(5.9)
<1 month 2 (22.2) 1(11.1) 4(44.4) 2 (22.2) 0 (0.0) 0(0,0)
Duration 1–2 months 0 (0.0) 0 (0.0) 1(20.0) 3(60.0) 1 (20.0) 0(0,0) 0.014*
≥3 months 5(14.2) 9(25.8) 8(22.9) 7 (20.0) 5(14.2) 1(2,9)
*statistically significant