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                                                       46
           making it susceptible to fracture.  Conversely, Lee et al.  re-  Confidentiality of data. The authors declare that no patient
           ported that incorporating only 0.5wt% of nGO significantly   data appear in this article.

           enhanced FS and FM. Nevertheless, higher nGO concentrations
           (1wt% and 2wt%) showed decreased FS values (lower than the   Right to privacy and informed consent. The authors declare
                                                              that no patient data appear in this article.
           control). These contradictory results can be explained by dif-
           ferences between the two studies in the processes of graphene
           addition to resin and oral-environment stimulation before the   CRediT authorship contribution statement
                               44
           bending tests. Gosh et al.,  kept the samples in water at 37ºC
                                    46
           for two weeks, while Lee et al.   kept them for only 48h. Di   Helena Salgado:  Conceptualization, Methodology, Project
           Carlo et al.  also observed a significantly higher FS and FM in   administration, Formal analysis, Data curation,  Writing—
                   43
           G-CAM resin compared to PMMA resin; however, the % of   original draft. Patrícia Fonseca: Conceptualization, Method-
           graphene in G-CAM resin in that study is unknown and may   ology, Formal analysis, and interpretation, Data curation,
                                                 47
           explain the difference in results. Agarwalla et al.  evaluated   Validation.  Pedro Mesquita:  Writing—review and editing,
           the BFS to characterize the mechanical strength and reliabili-
           ty of the materials and verified a higher BFS in graphene resin,   Validation, Supervision.  Maria Helena Figueiral:  Formal
           although without statistical significance. Once again, the ab-  analysis, Data curation, Writing—review and editing, Valida-
           sence of information regarding the % of graphene contained   tion. Mário Vaz: Writing—review and editing, Validation.
           in the resin makes it difficult to interpret and compare the
           results with other studies.                        orcid
             The IS of a material is defined as its capability to resist a
           sudden applied load or force. In prosthodontics, it is an im-  Helena Salgado    0000-0001-9134-6688
                                                         48
           portant predicting factor of clinical performance. Leite et al.    Patrícia Fonseca    0000-0002-1500-8465
           verified an improvement of IS in the specimens with a lower
           % of graphene (1/5 and 1/4) compared to those without   Mário Vaz    0000-0002-6347-9608
           graphene. Once again, the lower graphene concentrations   Maria Helena Figueiral    0000-0001-8583-8096
           showed to be the most efficient in improving the mechanical   Pedro Mesquita    0000-0003-0735-2482
           properties of the resin. This finding agrees with Alamgir et
           al.  results, despite having evaluated different mechanical
             45
           properties.                                        references
             Limitations of this systematic review include obtaining re-
           duced and heterogeneous articles after the selection process.   1. Nagaraj E, Mankani N, Madalli P, Astekar D. Socioeconomic
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           systematic review, we can draw the following conclusions:     4. Fernandes M, Júnior C, Oliveira S, Martins R, Fernandes J,
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           tive studies are required; 2) Graphene offers important quali-  Port Estomatol Med Dent Cir Maxilofac. 2022;63:117-25.
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                                                                 Microhardness and flexural strength after thermal aging.
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           Further studies are necessary to understand the ideal   6. Redtenbacher J. Ueber die zerlegungsprodukte des
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                                                                 Ann Chem. 1843;47:113–48.
                                                               7. Andreopoulo A, Papanicolaou G. Rubber-modified polymer
           Conflict of interest                                  composites. J Mater Sci. 1987;22:3417–20.
                                                               8. Gautam R, Singh R, Sharma V, Siddhartha R, Chand P, Kumar
                                                                 R. Biocompatibility of polymethylmethacrylate resins used in
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                                                               9. Hassan M, Asghar M, Din S, Zafar M. In Thermoset
                                                                 Polymethacrylate-Based Materials for Dental Applications.
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